Tuberculosis is (TB) a bacterial disorder caused by an acid fast bacillus. The treatment of TB is necessary in order to prevent its transmission to health individuals. The span of therapy could vary from six to nine months depending upon the type of TB. For example to cure latent TB usually nine months treatment is required.
Adherence to drug therapy is the major problem for most of the TB patients. One of the common reasons of this poor compliance rate is the side effects induced by TB drugs. Here is a list of some common side effects caused by Anti TB therapy with their treatment.
|No.||Side effects||Type of drugs||Intervention|
Minor Side Effects (Continue drug therapy)
|01||Loss of appetite, Abdominal pain, Nausea
|Advise the patient to take your drugs with small meals|
|02||Joint pain||Isoniazid||Use NSAIDs like aspirin|
|03||Sensation of burning in feet||Isoniazid||Use vitamin B6 (Pyridoxin) 100mg daily|
|04||Red or orange color urine||Rifampicin||It’s harmless and does not require any treatment|
|05||Skin rashes, Itching||Rifampicin, Isoniazid, Streptomycin||Refer your patient to TB center (where treatment is available)|
Major Side Effects (Discontinue drug therapy)
|01||Deafness (ototoxicity)||Streptomycin||Refer your patient to TB center (where treatment is available)|
|02||Jaundice (yellowish discoloration of urine, eye, and body)||Most anti- Drugs||Refer your patient to TB center (where treatment is available)|
|03||Visual impairment (peripheral neuritis)||Ethambutol||Refer your patient to TB center (where treatment is available)|
|04||Shock, abnormal urination, skin rashes, exanthema and pruritus||Ethambutol||Refer your patient to TB center (where treatment is available)|
Above list is comprises of only some common adverse effects of Anti-Tb therapy. There will be number of other adverse effects that will be suffered by patients.
- Arbex et al. Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 1: first-line drugs. J. bras. pneumol. vol.36 no.5 São Paulo Sept./Oct. 2010
- World Health Organization
- Current Medical and Diagnosis and Treatment (CMDT), 2014.
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