A new anti-fungal plastic derived treatment has been developed by scientists that has shown efficacy against fluconazole resistant strains. This study was published in the journal of Nature Communication. To determine the effectiveness of this new and novel treatment, mouse model was used.
The major portion of this new molecule is polyethylene terephthalate plastic. Since they have a positive charge so they can combine with the cell surface of fungi having a negative charge causing cellular catastrophe.
When this new anti-fungal treatment was applied topically to the eye of a rabbit suffering from fungal keratitis (eye infection), there was a similar reduction in viable count of fungal colonies as was resulted from amphotericin B (p= 0.05).
The researchers concluded that there was compatibility of this anti-fungal treatment in mammals and no abnormality in the eyes of rabbits was seen after its application. The most important aspect like the resistance against the therapy was also evaluated after giving repetitive subtherapeutic doses and there was no resistance developed.
Reference: K. Fukushima, S. Liu, H. Wu, A. C. Engler, D. J. Coady, H. Maune, J. Pitera, A. Nelson, N. Wiradharma, S. Venkataraman, Y. Huang, W. Fan, J. Y. Ying, Y. Y. Yang, and J. L. Hedrick, ‘Supramolecular High-Aspect Ratio Assemblies with Strong Antifungal Activity’, Nat Commun, 4 (2013), 2861. doi:10.1038/ncomms3861
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