Researchers have discovered a new protein named as isocitrate dehydrogenase (IDH1) that can act as a marker to detect lung cancer. This study was published in the journal of Clinical Cancer Research.
“This study is the first to report identification of IDH1 as a novel biomarker for the diagnosis of non-small cell lung cancers (NSCLC) using a large number of clinical samples,” said Jie He, M.D., Ph.D., director of the Laboratory of Thoracic Surgery at the Peking Union Medical College and Chinese Academy of Medical Sciences in Beijing. “Lung cancer has a high mortality rate, mostly because of late diagnosis. With an increase in aging population, we are likely to see an increase in lung cancer incidence and a need for better biomarkers for early diagnosis. We have identified IDH1 as an effective plasma biomarker with high sensitivity and specificity in the diagnosis of NSCLC, especially lung adenocarcinoma.”
Lung cancer target equally both men and women. There are different types of biomarkers such as CEA, Cyfra21-1 and CA125 that has already been discovered but these are not very sensitive as cautioned by He.
The researchers were able to detect lung cancer by measuring IDH1 levels in the blood of patients having 76% sensitivity and 77% specifity. There was a significant increase in sensitivity when IDH1 was used with existing biomarkers including CEA, Cyfra21-1, and CA125.
“Based on the present data, IDH1 can be used to detect stage 1 lung cancer; however, it is also possible that IDH1 could be used to detect precancer but further studies are required to address that possibility,” said He.
This study was conducted on controlled participants (479) and patients suffering from NSCLC (943).
“Our research also suggests IDH1 may be involved in the development of lung cancer, and it may be a good target for the treatment of NSCLC,” said He. His team is currently studying the molecular mechanisms that increase IDH1 in lung cancer patients and its clinical implications.
Reference: Nan Sun, Zhaoli Chen, Fengwei Tan, Baihua Zhang, Ran Yao, Chengcheng Zhou,Jiagen Li, Yibo Gao, Ziyuan Liu, Xiaogang Tan, Fang Zhou, Max Y.F He,Kang Shao, Ning Li, Bin Qiu, Jian Sun, Yue Yu, Suya Wang, Yuda Zhao,Xuejiao Shi, and Jie He. Isocitrate Dehydrogenase 1 Is a Novel Plasma Biomarker for the Diagnosis of Non–Small Cell Lung Cancer. Clin Cancer Res. 2013. doi: 10.1158/1078-0432.CCR-13-0046