The risk of heart diseases could be increased in women with kidney stones, according to the latest study published in the Journal of American Medical Association (JAMA) but this risk was absent in men.
“A link between kidney stones and cardiovascular risk factors has been long suspected, however studies on the association with cardiovascular outcomes that take into consideration important aspects such as dietary factors or medications are lacking,” said lead researcher Dr. Pietro Manuel Ferraro, a nephrologist at Columbus-Gemelli Hospital in Rome.
“Our study suggests that having kidney stones carries a higher risk of developing coronary disease in women independent of known cardiovascular risk factors such as diabetes or high blood pressure,” he said.
It has not yet been clear that why this risk is higher, said by Ferraro.
A possible explanation for the observed differences might be related to potential hormonal differences between men and women. Also, known differences in calcium metabolism between men and women might partly explain our findings,” he suggested.
These findings are not trustworthy as suggested by Dr. Michael Palese, an associate professor of urology at the Icahn School of Medicine at Mount Sinai Medical Center in New York City.
“Previous studies have been inconsistent in evaluating the connection between kidney stones and heart disease,” he said.
” Palese added. “These findings should be taken with a grain of salt.”
“While there are a number of potential mechanisms by which kidney stones could result in a higher risk for heart disease, it is not clear why these mechanisms would be only operative in women as suggested by this new study,” Fonarow said.
“Obesity, abdominal obesity or waist circumference [and body mass index] are associated with increased risk of kidney stone formation. This ties into the risk of heart disease since it is influenced by the same risk factors,” Okeke said.
Reference: Pietro Manuel Ferraro, MD; Eric N. Taylor, MD, MSc; Brian H. Eisner, MD; Giovanni Gambaro, MD, PhD; Eric B. Rimm, ScD; Kenneth J. Mukamal, MD, MPH, MA; Gary C. Curhan, MD, ScD. History of Kidney Stones and the Risk of Coronary Heart Disease. JAMA. 2013;310(4):408-415. doi:10.1001/jama.2013.8780.
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