The bacteria produces resistant against drugs by using a novel mode of communication according to the latest study published in the journal of Plos One. This study was conducted by using Burkholderia cenocepacia (B. cenocepacia) that causes severe infections in patients whose immune system is compromised such as patients suffering from cystic fibrosis.
Researchers found that small molecules located in B. cenocepacia not only make the cells resistant of B. cenocepacia but also protect other microbes such as E.Coli and seudomonas aeruginosa.
“These findings reveal a new mechanism of antimicrobial resistance based on chemical communication among bacterial cells by small molecules that protect against the effect of antibiotics,” says Dr. Valvano, adjunct professor in the Department of Microbiology and Immunology at Western’s Schulich School of Medicine & Dentistry, currently a Professor and Chair at Queen’s University Belfast. “This paves the way to design novel drugs to block the effects of these chemicals, thus effectively reducing the burden of antimicrobial resistance.”
“These small molecules can be utilized and produced by almost all bacteria with limited exceptions, so we can regard these small molecules as a universal language that can be understood by most bacteria,” says El-Halfawy, who called the findings exciting. ”
Source: University of Western Ontario
Reference: El-Halfawy OM, Valvano MA (2013) Chemical Communication of Antibiotic Resistance by a Highly Resistant Subpopulation of Bacterial Cells. PLoS ONE 8(7): e68874. doi:10.1371/journal.pone.0068874
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