Risk of prostate cancer is two times higher in men with sleep problems according to the latest study published in the journal of Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
“Sleep problems are very common in modern society and can have adverse health consequences,” said Lara G. Sigurdardóttir, M.D., at the University of Iceland in Reykjavik. “Women with sleep disruption have consistently been reported to be at an increased risk for breast cancer, but less is known about the potential role of sleep problems in prostate cancer.”
There are some conflicting results of the previous studies regarding the link between sleep deprivation and risk of prostate cancer.
Researchers enrolled 2,425 men having age in between 67 to 96 years and they were asked four basic questions about their sleep disruption such as,
- Whether they took medication or not for inducing sleep
- Whether they have some type of trouble during sleeping and etc.
According to their findings, 8.7 percent and 5.7 percent of the total participants had severe sleep problems. There was no patient who was suffering from prostate cancer during the start of the study. This study was continued for a period of five years during which researchers followed all the participants to determine the possible risk of prostate cancer. They found that during follow up period 6.4% enrolled participants were diagnosed with prostate cancer.
The risk of prostate cancer was 1.6 to 2.1 times more in men depending upon their severity in falling and staying asleep. If the problems are more severe than the risk of advance prostate cancer is three times more.
According to Sigurdardóttir, these data should be confirmed with a larger cohort with longer observation times. “Prostate cancer is one of the leading public health concerns for men and sleep problems are quite common,” she said. “If our results are confirmed with further studies, sleep may become a potential target for intervention to reduce the risk for prostate cancer.”
The abstract of this article is as follows.
Background: Although positive associations have consistently been reported between sleep disruption and breast cancer, less is known about its potential role in prostate cancer.
Methods: Within the prospective AGES-Reykjavik cohort study, we followed 2,102 men recruited in 2002–2006 until the end of 2009. Participants answered questions on sleep disruption. Information on the occurrence of prostate cancer was obtained through record linkages across the Icelandic Cancer Registry. We used Cox regression models with 95% confidence intervals (CI) to estimate HRs of prostate cancer by symptoms of sleep disruption.
Results: During follow-up, 135 men (6.4%) were diagnosed with prostate cancer. Compared with men without sleep disruption, those with problems falling and staying asleep were at significantly increased risk of prostate cancer [HR, 1.7 (95% CI, 1.0–2.9) and 2.1 (95% CI, 1.2–3.7)], respectively, with increasing sleep disruption severity. When restricted to advanced prostate cancer (≥ stage T3 or lethal disease), these associations became even stronger [HR 2.1 (95% CI, 0.7–6.2) and 3.2 (95% CI, 1.1–9.7)]. The results did not change after excluding from the analyses men who woke up during the night, indicative of nocturia, suggesting limited risk of reverse association.
Conclusions: Our data suggest that certain aspects of sleep disruption may confer an increased risk of prostate cancer and call for additional, larger studies with longer follow-up times.
Reference: Lara G. Sigurdardottir, Unnur A. Valdimarsdottir, Lorelei A. Mucci, Katja Fall, Jennifer R. Rider, Eva Schernhammer, Charles A. Czeisler, Lenore Launer, Tamara Harris, Meir J. Stampfer, Vilmundur Gudnason, Steven W. Lockley. 2013. Sleep Disruption Among Older Men and Risk of Prostate Cancer. Cancer Epidemiol Biomarkers Prev; 22(5); 872–9.
Copyright 2012 Medimoon.com. All rights reserved. No part of this site can be reproduced without our written permission.None found.