A newer system of drug delivery for the treatment of lung cancer has been discovered by researchers in which patient will inhale anti-cancer drugs (chemotherapeutic), according to the study published in the Journal of Controlled Release.
Lung cancer targets both men and women and increasing the rate of mortality day by day. Different mode of treatments is being used for the treatment of lung cancer including advanced surgical methods and chemotherapy but chemotherapy is most commonly used treatment despite of tremendous advancement in surgical methods. Some patients are unable to tolerate chemotherapy due to severe toxic effects and unavailability of drug at the site of action.
“Lung cancer damage is usually not localized, which makes chemotherapy an important part of treatment,” said Taratula, an assistant professor in the OSU College of Pharmacy and co-author of this study. “However, the drugs used are toxic and can cause organ damage and severe side effects if given conventionally through intravenous administration.
“A drug delivery system that can be inhaled is a much more efficient approach, targeting just the cancer cells as much as possible,” he said. “Other chemotherapeutic approaches only tend to suppress tumors, but this system appears to eliminate it.”
The company is in run to apply for a patent for this new technology and further testing will be carried out to determine safety and effectiveness by conducting clinical trials in humans.
The basic part of this system is “nanostructured lipid nanocarrier,” consisted of very small particles (size less than the speck of dust) that can be inhaled without any problem and can reach the lungs easily. An anti cancer drug used for lung cancer treatment can be targeted by using this carrier system.
Cancer cells usually offer two types of resistance. On in which drug is expelled out and in the second case, resistance facilitates keep the cells from dying. In this system, researchers have used small interfering RNA (siRNA) that can eradicate both types of resistance and increases the rate of destruction of cancerous cells.
The chemotherapeutic drugs can undergo degradation when injected that will not occur if inhaled as stated by researchers.
More importantly the drugs used under conventional methods also reside in the liver, spleen and very small amount of the drug actually reaches the targeted organ but when the same drug is inhaled than approximately 83% drug reaches into the lungs which was only 23% by injection.
Source: Oregon State University
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