Exotoxins are toxic substances secreted by bacteria and released outside the cell. Whereas Endotoxins are bacterial toxins consisting of lipids that are located within a cell. Following are the few differences between exotoxin and endotoxin.
|Source||Living gram positive and gram negative bacteria||Lysed gram negative bacteria|
|Location||Released from the cell||Part of cell|
|Heat Sensitivity||Liable (60-80C)||Stable (250C)|
|Conversion to Toxoids||Possible||Not possible|
|Enzyme Activity||It has mostly enzymatic activity.||It has no enzymatic activity.|
|Molecular Weight||Its molecular weight is 10KDa.||Its molecular weight is 50-1000KDa.|
|Denaturing||On boiling it get denatured.||On boiling it cannot be denatured.|
|Specificity||Specific to particular bacterial strain||Non specific|
|Examples||Staphylococcus aureus, Bacillus cereus, Streptococcus pyogenes, Vibrio cholera, Bacillus anthrcis.||E.coli, Salmonella typhi, Shigella.|
Nagina Anwar is a brilliant student of Pharm D of Hajvery University Lahore. She has helped in compilation of this article.
Pommerville JC. Alcamo’s Fundamentals of Microbiology: Body Systems. Jones & Bartlett Learning, 2009; p626.
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