The odds of developing carcinoma of the lung linked to asbestos exposure, asbestosis and smoking are dramatically increased when these three risk factors are combined, and quitting smoking significantly reduces the risk of developing cancer of lung after long-term asbestos exposure, in accordance with new information.
“The interactions between asbestos exposure, asbestosis and smoking, and their influence on lung cancer risk are incompletely understood,” said lead author Steven B. Markowitz, MD DrPH, professor of occupational and environmental medicine at the School of Earth & Environmental Sciences at Queens College in New York. “In our study of a large cohort of asbestos-exposed insulators and more than 50,000 non-exposed controls, we found that each individual risk factor was associated with increased risk of developing lung cancer, while the combination of two risk factors further increased the risk and the combination of all three risk factors increased the risk of developing lung cancer almost 37-fold.”
The findings were published online prior to print publication in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.
The learning included 2,377 long-term American insulators and 54,243 male blue collar workers without any good reputation for experience of asbestos in the Cancer Prevention Study II. Reasons for death were determined through the National Death Index.
Among non-smokers, asbestos exposure increased the incidence of dying from united states 5.2-fold, while blend of smoking and asbestos exposure increased the fatality rate more(a) 28-fold. Asbestosis increased the risk of developing lung cancer among asbestos-exposed subjects in both smokers and non-smokers, while using the fatality rate from united states increasing 36.8-fold among asbestos-exposed smokers with asbestosis.
Among insulators who give up smoking cigarettes, united states morality dropped within the ten years following smoking cessation from 177 deaths per 10,000 among current smokers to 90 per 10,000 one of those who quit. Lung cancer rates among insulators who had stopped smoking more than 30 years earlier were much like those among insulators who had never smoked.
There were a couple of limitations to the study, such as idea that smoking status and asbestosis were evaluated one time understanding that some members in the control group happens to be confronted with relatively brief periods of asbestos.
“Our study provides strong evidence that asbestos exposure causes lung cancer through multiple mechanisms,” said Dr. Markowitz. “Importantly, we also show that quitting smoking greatly reduces the increased lung cancer risk seen in this population.”
Source: American Thoracic Society
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