Omega 3-fatty acids do not reduce the risk of postoperative atrial fibrillation or flutter (AF) according to the latest research published in the journal of American Medical Association (JAMA). The most common complication of cardiac surgery is postoperative atrial fibrillation that can increase the rate of morbidity and health care utilization.
The Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) double-blind, placebo-controlled, randomized clinical study was conducted on 1516 patients undergoing cardiac surgery in 28 centers in the United States, Italy, and Argentina between August 2010 and June 2012.
Fish oil (1-g capsules containing ≥840 mg n-3-PUFAs as ethyl esters) and placebo was given to all patients randomly, at a dose of 10 g for period of 3 to 5 days (or 8 g over 2 days) before operation and followed by 2 g per day after operation until hospital discharge or for a period of 10 days.
“At enrollment, mean age was 64 (SD, 13) years; 72.2% of patients were men, and 51.8% had planned valvular surgery. The primary end point occurred in 233 (30.7%) patients assigned to placebo and 227 (30.0%) assigned to n-3-PUFAs (odds ratio, 0.96 [95% CI, 0.77-1.20]; P = .74). None of the secondary end points were significantly different between the placebo and fish oil groups, including postoperative AF that was sustained, symptomatic, or treated (231 [30.5%] vs 224 [29.6%], P = .70) or number of postoperative AF episodes per patient (1 episode: 156 [20.6%] vs 157 [20.7%]; 2 episodes: 59 [7.8%] vs 49 [6.5%]; ≥3 episodes: 18 [2.4%] vs 21 [2.8%]) (P = .73). “
Patient did not suffer any bleeding problems or other serious side effects after taking n-3-PUFAs.
At the end of large multinational trial researchers concluded that risk of postoperative AF does not reduce after taking preoperative supplementation with n-3-PUFAs, compared with placebo.
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Dariush Mozaffarian, MD, DrPH; Roberto Marchioli, MD; Alejandro Macchia, MD; Maria G. Silletta, MS; Paolo Ferrazzi, MD; Timothy J. Gardner, MD; Roberto Latini, MD; Peter Libby, MD; Federico Lombardi, MD; Patrick T. O’Gara, MD; Richard L. Page, MD; Luigi Tavazzi, MD; Gianni Tognoni, MD; for the OPERA Investigators. “Fish Oil and Postoperative Atrial FibrillationThe Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) Randomized Trial” AMA. 2012;():1-11. doi:10.1001/jama.2012.28733.
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