Research published in The New England Journal Of Medicine (NEJM) has shown that risk of death is more in critically ill patients due to moderate and severe hypoglycemia. Hyperglycemia is common people who are being treated in intensive care unit (ICU) and its severe form could increase the risk of mortality and morbidity.
This study was conducted on 6104 critically ill patients in intensive care unit (ICU). The researchers tried to determine association between moderate 41 to 70 mg per deciliter [2.3 to 3.9 mmol per liter] and severe hypoglycemia ≤40 mg per deciliter [2.2 mmol per liter] and risk of death.
Out of 6026 patients: 2714 (45.0%) were suffering from moderate hypoglycemia, 2237 of whom (82.4%) were in intensive control group and 223 patients (3.7%) were suffering from severe hypoglycemia, 208 of whom (93.3%) were in the intensive-control group.
Researchers found that “Of the 3089 patients who did not have hypoglycemia, 726 (23.5%) died, as compared with 774 of the 2714 with moderate hypoglycemia (28.5%) and 79 of the 223 with severe hypoglycemia (35.4%).”
From above it was clear that risk of death is significantly higher in people suffering from moderate and severe hypoglycemia as compared to those who did not have hypoglycemia.
According to the researchers, “For both moderate and severe hypoglycemia, the association was strongest for death from distributive shock. In addition, the association was stronger among patients with severe hypoglycemia than among those with moderate hypoglycemia, and was stronger among those with moderate hypoglycemia that occurred on more than 1 day than among those with moderate hypoglycemia on only 1 day”
This research was funded by the Australian National Health and Medical Research Council and others; NICE-SUGAR ClinicalTrials.gov number, NCT00220987.
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1. Inzucchi SE. Management of hyperglycemia in the hospital setting. N Engl J Med 2006;355:1903-11.
2. Bochicchio GV, Joshi M, Bochicchio KM, et al. Early hyperglycemic control is important in critically injured trauma patients. J Trauma 2007;63:1353-8.
3. Freire AX, Bridges L, Umpierrez GE, Kuhl D, Kitabchi AE. Admission hyperglycemia and other risk factors as predictors
of hospital mortality in a medical ICU population. Chest 2005;128:3109-16.
4. Krinsley JS. Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients. Mayo Clin Proc 2003;78:1471-8.
5. Taylor JH, Beilman GJ. Hyperglycemia in the intensive care unit: no longer just a marker of illness severity. Surg Infect (Larchmt) 2005;6:233-45.
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