Scientists have discovered a new protein that could be considered as a potential target for the treatment and management of diabetes. This new protein, A-kinase anchoring proteins or AKAPs effects blood glucose level. Different drug molecules can be made that can alter the functions of AKAPs. This research was published in the journal of Nature.
During this research scientist have utilized imaging technique combined with mice and genetically modified insulin cells. They found
“The scientists were able to show glucose control came from a seven-amino-acid sequence in the anchor protein that directly interacts with the surface of phosphatase enzyme.”
Phosphatases are those enzymes which play very important role in regulation of molecular events to control blood glucose level. The positioning of theses phosphatases is under the control of AKAPs.
“Our discovery that anchored enzymes contribute to the regulation of cellular events that underlie diabetes may help us to move more rapidly toward new therapies to control this increasingly prevalent metabolic disease,” commented John Scott, Edwin G. Krebs–Hilma Speights Professor of Pharmacology at the University of Washington School of Medicine, Seattle and an investigator of the Howard Hughes Medical Institute in a press release.
The goal of this research could be to increase the sensitivity of insulin in skeletal muscles by targeting A-kinase anchoring proteins that can affect phosphatases.
You can read full research article here.
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