Latest research published in Canadian Medical Association Journal has indicated that one class of Antidiabetic drug may increase the risk of bladder cancer.
According to the WHO diabetes can be defined as,
“The term “diabetes mellitus” describes a metabolic disorder of multiple aetiology characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both”.
There are almost 346 million people who are suffering from diabetes mellitus and in 2004 3.4 million people died due to increased blood sugar. (WHO)
Now this recent research may increase the rate of death among diabetic patients due to drug induced bladder cancer. The researchers have conducted a systematic review and meta-analysis to determine the chances of bladder cancer in adults suffering from type 2 diabetes mellitus using thiazolidinediones. They suggested that type 2 diabetic patients have 40% more chances of development of cancer.
This study was conducted on more than 2.6 million diabetic patients. Among them, 3,643 were those diabetic patients who were recently diagnosed bladder cancer.
Yeffrey Johnson of the School of Public Health at the University of Alberta gives the statement that,
“We observed an increased risk of bladder cancer associated with the use of thiazolidinediones,”
He further added,
“In particular, use of pioglitazone was associated with an increased risk of bladder cancer based on a pooled estimate from three cohort studies involving more than 1.7 million individuals.”
This study was also done on another drug named as rosiglitazone (another type of thiazolidinedione), but researchers have not determined any effect fortunately.
Researchers give a very useful statement that,
“Although the absolute risk of bladder cancer associated with pioglitazone was small, other evidence-based treatments for Type 2 diabetes may be equally effective and do not carry a risk of cancer,”
This study is very helpful for physicians who are specialist in diabetes management and treatment. It would be very healthy for patients if they are not prescribed pioglitazone rather there are various other Antidiabetic drugs that could be prescribed and they do not have any carcinogenic effect.
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